MersV1, Main, Exploration, bibRecord, 004097

Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription

Identifieur interne : 004097 ( Main/Exploration ); précédent : 004096; suivant : 004098

Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription

Auteurs : Claudine Boiziau [France] ; Françoise Debart [France] ; Bernard Rayner [France] ; Jean-Louis Imbach [France] ; Jean-Jacques Toulme [France]

Source :

FEBS Letters [ 0014-5793 ] ; 1995.

RBID : ISTEX:62471EB490EF3633C624B14CCBBA791D929275DA

English descriptors

Teeft :
- Alpha stretch, Antisense, Antisense oligomer, Antisense oligonucleotide, Antisense oligonucleotides, Beta, Beta stretch, Boiziau, Cdna, Cdna synthesis, Chimera, Chimeric, Chimeric oligonucleotides, Cleavage, Duplex, Hybrid, Mmlv, Moloney murine leukemia virus, Nucleic, Nucleic acids, Nucleotide, Oligomers, Oligonucleotide, Oligonucleotides, Pmol, Primer, Radiolabeled, Rnase, Transcription, Unmodified.

Abstract

Abstract: Alpha-beta chimeric 17-mer oligodeoxyribonucleotides containing either 5, 10 or 15 beta nucleotides were synthesized. The stability of the RNA/chimera hybrids was only slightly affected by the alpha stretch and by the alpha-beta link, as was the affinity of the Moloney Murine Leukemia Virus reverse transcriptase for the duplexes. All chimeras inhibited in vitro cDNA synthesis in a cell-free system to various extent, via the degradation of the RNA target by RNase H.

Url:

https://api.istex.fr/ark:/67375/6H6-8HV2TJXR-B/fulltext.pdf

DOI: 10.1016/0014-5793(95)00138-Y

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001061
to stream Istex, to step Curation: 001061
to stream Istex, to step Checkpoint: 001788
to stream Main, to step Merge: 004158
to stream Main, to step Curation: 004097

Le document en format XML

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<author><name sortKey="Rayner, Bernard" sort="Rayner, Bernard" uniqKey="Rayner B" first="Bernard" last="Rayner">Bernard Rayner</name>
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<author><name sortKey="Imbach, Jean Louis" sort="Imbach, Jean Louis" uniqKey="Imbach J" first="Jean-Louis" last="Imbach">Jean-Louis Imbach</name>
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<author><name sortKey="Toulme, Jean Jacques" sort="Toulme, Jean Jacques" uniqKey="Toulme J" first="Jean-Jacques" last="Toulme">Jean-Jacques Toulme</name>
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<term>Beta</term>
<term>Beta stretch</term>
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<term>Cdna</term>
<term>Cdna synthesis</term>
<term>Chimera</term>
<term>Chimeric</term>
<term>Chimeric oligonucleotides</term>
<term>Cleavage</term>
<term>Duplex</term>
<term>Hybrid</term>
<term>Mmlv</term>
<term>Moloney murine leukemia virus</term>
<term>Nucleic</term>
<term>Nucleic acids</term>
<term>Nucleotide</term>
<term>Oligomers</term>
<term>Oligonucleotide</term>
<term>Oligonucleotides</term>
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<term>Primer</term>
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<front><div type="abstract" xml:lang="en">Abstract: Alpha-beta chimeric 17-mer oligodeoxyribonucleotides containing either 5, 10 or 15 beta nucleotides were synthesized. The stability of the RNA/chimera hybrids was only slightly affected by the alpha stretch and by the alpha-beta link, as was the affinity of the Moloney Murine Leukemia Virus reverse transcriptase for the duplexes. All chimeras inhibited in vitro cDNA synthesis in a cell-free system to various extent, via the degradation of the RNA target by RNase H.</div>
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Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription

Chimeric alpha-beta oligonucleotides as antisense inhibitors of reverse transcription

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri